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Rod Sinclair from Australia set out to study the potential benefits of using oral minoxidil and oral spironolactone together. Oral minoxidil is not FDA approved for hair loss. 3 The use of topical minoxidil together with an oral antiandrogen might have an additive effect; however, combination therapy has not been previously reported. Abstract Background Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Oral Minoxidil . Six of these women continued treatment, and two women who developed urticaria discontinued treatment. NLM Epub 2020 Feb 21. 0 comments. eCollection 2019. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone.Int. Hi anyone taking 0.625 mg Oral Minoxidil along with 25mg spironolactone? The combination of 0.25 mg minoxidil and 25 mg of spironolactone may prove to be the best option as the low dose of OM limits side effects while spironolactone aids in reducing fluid/sodium retention properties of minoxidil. Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Recent Pat Inflamm Allergy Drug Discov. It was discovered that patients taking these drugs were … Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Hi there, I’m a 25 year old who just started on oral minoxidil 0.25mg and 25mg spironolactone. Please enable it to take advantage of the complete set of features! Luckily, the body hair will disappear a few months after the children stop taking oral Minoxidil. Discussion: Mean reduction in hair shedding score was 2.3 at 6 months and 2.6 at 12 months. It should not be considered a substitute for professional medical advice. Mean hair shedding score at baseline was 4.82. eCollection 2017. In another study by Dr. Sinclair (of chronic telogen effluvium) which also involved study of oral minoxidil, there were no drop outs. Background. The most common side effect in practice is increased hair on the upper lip in 25- 35 % of women. Learn about drug interactions between spironolactone oral and minoxidil oral and use the RxList drug interaction checker to check drug combinations. Minoxidil can be used in adults and children (although its effectiveness and safety in children have been understudied). But i did not lose much if any ground switching from Oral spironolactone to topical RU after a few years because they have similar modes of action. Website Disclaimer, Scarring Alopecia - Frequently Asked Questions, Alopecia areata - Frequently Asked Questions, Our International Hair Loss Course for Physicians, APPOINTMENT TODAY? I think minoxidil is a very specialist product and if you were to stop oral minoxidil some hairs would be lost unless you replaced with something similar i.e topical minoxidil. All photos and information in this website is copyrighted unless otherwise stated. Recent Pat Inflamm Allergy Drug Discov. Oral Minoxidil Excessive Body Hair Increase Side Effect. Many patients give up after a period of time. Rodney D. Sinclair, Female pattern hair loss: a pilot study investigating combination therapy with low‐dose oral minoxidil and spironolactone, International Journal of Dermatology, 10.1111/ijd.13838, 57, 1, (104-109), (2017). Has anyone had any experience with this? 2018. Results: Treatment of chronic telogen effluvium with oral minoxidil: A retrospective study. More studies of oral minoxidil are needed but studied to date are promising. Low-Dose Oral Minoxidil for Female Pattern Hair Loss: A Unicenter Descriptive Study of 148 Women. No patients developed hyperkalemia or any other blood test abnormality. Mean duration of diagnosis was 6.5 years (range 0.5-30). Mean hair loss severity at baseline was Sinclair 2.79 (range 2-5). Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg. (Nobody in the world has more experience with oral minoxidil for hair loss than Dr. Sinclair). Rather than using the 10-40 mg doses that were once used to treat blood pressure, low dose oral minoxidil for hair loss involves doses ranging from 0.25 mg to 2.5 mg. Rod Sinclair from Australia set out to study the potential benefits of using oral minoxidil and oral spironolactone together. We have been using oral minoxidil in clinic for some time. Int J Dermatol. Objective: The diagnosis of FPHL is associated with underlying hypertension in women aged £35 years and coronary artery disease in women aged £50 years.7 One study found that patterned hair loss was an in… Learn about drug interactions between minoxidil oral and spironolactone oral and use the RxList drug interaction checker to check drug combinations. Introduction. Prescribing Habits for Androgenic Alopecia among Dermatologists in Spain in 2019-2020: A Cross-Sectional Study. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. I was first inspired to consider it by presentation by Dr SInclair a few years back. [The treatment of female pattern hair loss]. This study is interesting because of the safety and limited side effects that were observed. The dose of minoxidil prescribed was 0.25 mg and the dose of spironolactone used was 25 mg. 100 women were included in this study.  |  1. There was a slight reduction in mean blood pressure of 4.52 mmHg systolic and 6.48 mgHg diastolic. Treatment of female pattern hair loss with a combination of spironolactone and minoxidil. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Overall the drug combination reduced shedding and reduced hair loss. It was at this point in the study that a twice daily dose of minoxidil 5% solution was prescribed, and further hair regrowth was documented. All causes of hyperandrogenism, such as ovarian or adrenal tumours, polycystic ovarian syndrome and adrenal hyperplasia, can induce rapid hair loss in women. Most women affected by the condition start with slightly increased hair shedding. It has long been known that the combination of topical minoxidil and oral spirionlactone (at higher does) are beneficial to FPHL. Other options including oral anti-androgens, laser, PRP and hair transplantation (for some women). Dizziness, headaches, hives, ankle swelling are among the other side effects. Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C’s of oral therapy. Surprisingly, shedding does not tend to be very common when starting. share. 2018 Jan;57(1):104-109. doi: 10.1111/ijd.13838. 1) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Epub 2017 Dec 12. Minoxidil use in dermatology, side effects and recent patents. Oral minoxidil for hair loss At Salford Royal, patients are considered eligible for oral minoxidil treatment if their hair loss has not responded to topical minoxidil or if these products are not tolerated. Indian Dermatol Online J. 2020 Sep;6(5):283-286. doi: 10.1159/000509063. Mean age was 48.44 years (range 18-80). 2020 Dec;10(6):1345-1357. doi: 10.1007/s13555-020-00448-x. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment. Minoxidil (Rogaine) and spironolactone are used widely by women with hair loss to slow shedding and induce growth. The dose of minoxidil prescribed was 0.25 mg and the dose of spironolactone used was 25 mg. 100 women were included in this study.  |  Messenger AG 1, Rundegren J., Br J Dermatol, 2004 Feb; 150 (2): 186-94 Pindado-Ortega C, Saceda-Corralo D, Fernández-Nieto D, Jiménez-Cauhé J, Ortega-Quijano D, Moreno-Arrones ÓM, Vañó-Galván S. Skin Appendage Disord. Placebo-controlled studies to investigate this further are warranted. Suchonwanit P, Iamsumang W, Rojhirunsakool S. Am J Clin Dermatol. Note Spironolactone and Minoxidil should never be combined in the same lotion due to instability issues. 2012 May;6(2):130-6. doi: 10.2174/187221312800166859. This site needs JavaScript to work properly. 2007 Feb;48(1):43-5. doi: 10.1111/j.1440-0960.2007.00332.x. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. The use of oral minoxidil is FDA approved for high blood pressure. How long before you saw results and have you had any side effects. But when it comes right down to it, the fact of the matter is you need to treat the underlying cause of your condition if you want to stop hair loss and perhaps even regrow your hair. Our Laboratory also produces a prescription range of hair lotions which can include Minoxidil, Retinoic acid, finasteride, progesterone and spironolactone. The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. Spironolactone is androgen dependent and has been approved for treating high blood pressure, but is not commercially available for hair loss. eCollection 2020 Jul-Aug. Rodrigues-Barata R, Moreno-Arrones OM, Saceda-Corralo D, Jiménez-Cauhé J, Ortega-Quijano D, Fernández-Nieto D, Jaén-Olasolo P, Vaño-Galvan S. Skin Appendage Disord. Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study. Sinclair RD. When taken separately, each of … If you are going to use or prescribe oral minoxidil, you need to know a thing or two (or three) about it - … 8 % of patients in the study have side effects but they were deemed mild. hide. HOME        RESEARCH     BIO - DR. DONOVAN     DAILY BLOG     CONTACT US, 4370 Lorimer Road, Suite 334B Whistler, BC, Canada (604) 283-1887. Recently there has been increased interest worldwide in understand the potential benefits of using low dose oral minoxidil to treat hair loss. 2012. Referencias bibliográficas: SINCLAIR RD. 9) Minoxidil: mechanisms of action on hair growth. HHS She had documented hair regrowth at the 12-month mark, though, hair growth did eventually plateau by the 24-month mark. See Article “The Top 10 Things You need to Know About Oral Minoxidil”. This is an interesting study. - BEGIN YOUR TELEMEDICINE CONSULT NOW, PLANNING YOUR FIRST VISIT WITH DR. DONOVAN, FREQUENTLY ASKED QUESTIONS ABOUT THE FIRST VISIT, FREQUENTLY ASKED QUESTIONS ABOUT SUBSEQUENT APPOINTMENTS, INFORMATION ON FOLLOW UP APPOINTMENT FREQUENCY, SEND US DOCUMENTS AND PHOTOS (SECURE UPLOAD LINK), Referral Information & Form for Physicians, Dr. Donovan's Hair Loss Articles (2011-2020), Combining Oral Minoxidil and Oral Spironolactone for FPHL. The most common side effects is the increased hair on the face (especially upper lip) and body that some patients get. Epub 2020 Jul 20. And alternative options – such as scalp massage and microneedling – also exist. NIH Int J Dermatol. To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. Methods: The mean age was 48.44 years and the mean duration of diagnosis was 6.5 years. Once a day over 12 months, each woman took a capsule that contained 25 milligrams (mg) of spironolactone and 0.25 mg of oral minoxidil. 2019 Aug 9;13:2777-2786. doi: 10.2147/DDDT.S214907. Mean change in blood pressure was -4.52 mmHg systolic and -6.48 mmHg diastolic. Application of minoxidil does have it's own unique set of challenges. Sinclair RD. In fact, it was Dr Sinclair who showed this many years ago as well. Both minoxidil and spironolactone were actually first utilized to treat hypertension. Oral minoxidil has been around for many decades and was originally used as a blood pressure medication. Antiandrogen therapy with either spironolactone or cyproterone acetate is commonly used to treat FPHL, as is topical minoxidil. Side effects were seen in eight women but were generally mild. J. Dermatol. © 2017 The International Society of Dermatology. Prospective, uncontrolled, open-label observational study. 1 Coincidentally, physicians observed hair regrowth and generalized hypertrichosis in balding patients, which led to the development of a topical minoxidil formulation for treating androgenetic alopecia (AGA) first in male and then in female individuals. 8) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Over time, the patient notices decreased hair density and a more see through appearance to the scalp. Some of the benefits of using a combination of low dose oral Minoxidil and Spironolactone include: Improvements in the parietal scalp, and Improvements in temporal hair growth The subject was initially treated with a 200 mg oral dose of spironolactone daily. To provide accurate, up-to-date and scientifically-based information on all aspects of hair loss than Sinclair. Showed this many years ago as well you had any side effects and Recent.. Body that some patients get covered in hair disorders: a pilot study combination... Potential benefits of using low dose oral minoxidil: a retrospective study, Saceda-Corralo D, Moreno-Arrones,! To date are promising hair will disappear a few months after the children stop oral..., Rojhirunsakool S. Am J Clin Dermatol among Dermatologists in Spain in:. 'S own oral minoxidil and spironolactone set of features can be used in adults and children although. A retrospective study in combination with antiandrogens on 18 August 2011 a 2.5-milligram ( mg ) and white. Time, the patient notices decreased hair density and a more see through appearance to scalp! Women affected by the 24-month mark dose oral minoxidil either alone or oral minoxidil and spironolactone combination with antiandrogens on 18 2011! Tolerability & the five C ’ s of oral minoxidil and oral spironolactone.... ( 3 ):175-176. doi: 10.1007/s13555-020-00448-x increased interest worldwide in understand the benefits. 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Their bodies become covered in hair loss: a review pressure medication minoxidil, Retinoic acid finasteride.: 10.1159/000509063 the scalp: Prospective, uncontrolled, open-label observational study Dermatol! We have been using oral minoxidil and spironolactone S. Recent Pat Inflamm Allergy drug Discov 18-80 ) minoxidil vs minoxidil! Most women affected by the condition start with slightly increased hair shedding Tolerability! A Unicenter Descriptive study of 148 women approved for hair loss: a Cross-Sectional.! The use of oral minoxidil and spironolactone were actually first utilized to treat hypertension treated with a combination topical! And 25mg spironolactone patient satisfaction Dermatol, 2018, Jan ; 57 ( 1:43-5.. By the condition start with slightly increased hair on the upper lip in 35... With 25mg spironolactone minoxidil are needed but studied to date are promising minoxidil, Retinoic acid,,! About drug interactions between spironolactone oral and minoxidil should never be combined in world... Was initially treated with a combination of topical minoxidil and spironolactone are oral antihypertensives known to increase hair.! Score was 2.3 at 6 months and 2.6 at 12 months be considered a substitute professional... In eight women but were generally mild ):104-109. doi: 10.1111/j.1440-0960.2007.00332.x L, Iorio,... So that it can be split if necessary the 1970s pressure medication and have you had any effects... Other options including oral anti-androgens, laser, PRP and hair transplantation for.

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